Fig. 1.

RA patients exhibit a higher number of Tm cells with high expression of CD147. a Representative FACS data show the expression of CD69 on CD4⁺ T cells in PBMCs from healthy donors (HD) and RA patients, and three samples of SF from the latter were detected. b Summary data of CD69 expression on CD4⁺ T cells in PBMCs from HD (n = 10) and RA patients (n = 15). Each symbol represents a value from a single donor. The horizontal lines denote the mean ± SD expression. c Summary data of CD69 expression on CD4⁺ T cells in PBMCs and SF from RA patients from three independent experiments are shown. d Detection of CD4⁺CD45RO⁺ T cells in PBMCs from HD (n = 7) and RA patients (n = 7). e Detection of CD4⁺CD45RO⁺ T cells in PBMCs and SF from RA patients (n = 3). f CD147 expression on different peripheral blood cells from HD and RA patients was determined by FACS. g Expression of CD147 on Tm and Tn cells in both RA patients and HD. *P < 0.05; **P < 0.01; ***P < 0.001