Table 2.
Relation of inflammatory biomarkers to insulin resistance and incident diabetes
| Biomarker | Model | QUICKI | HOMA2IR | Incident diabetes | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| N | β (95% CI) | P value | N | β (95% CI) | P value | Events/N | HR (95% CI) | P value | ||
| Log2sCD14 | Model 1 | 4,964 | −0.0027 (−0.0051, −0.0004) | 0.024 | 4,917 | 0.0899 (0.0001, 0.1797) | 0.050 | 427/4,448 | 0.92 (0.67, 1.29) | 0.641 |
| Model 2 | 4,894 | −0.0023 (−0.0045, −0.0001) | 0.031 | 4,847 | 0.0909 (0.0089, 0.1728) | 0.029 | 421/4,383 | 0.99 (0.70, 1.42) | 0.993 | |
| Log2IL-6 | Model 1 | 4,896 | −0.0066 (−0.0074, −0.0058) | <0.001 | 4,853 | 0.2516 (0.2220, 0.2812) | <0.001 | 431/4,401 | 1.33 (1.19, 1.47) | <0.001 |
| Model 2 | 4,828 | −0.0031 (−0.0039, −0.0023) | <0.001 | 4,785 | 0.1236 (0.0956, 0.1516) | <0.001 | 425/4,338 | 1.15 (1.03, 1.29) | 0.018 | |
| Log2CRP | Model 1 | 5,265 | −0.0038 (−0.0042, −0.0034) | <0.001 | 5,217 | 0.1407 (0.1236, 0.1577) | <0.001 | 464/4,724 | 1.20 (1.12, 1.27) | <0.001 |
| Model 2 | 5,191 | −0.0016 (−0.0020, −0.0012) | <0.001 | 5,143 | 0.0616 (0.0455, 0.0776) | <0.001 | 458/4,655 | 1.09 (1.02, 1.16) | 0.017 | |
| Log2WBC | Model 1 | 5,279 | −0.0133 (−0.0149, −0.0117) | <0.001 | 5,232 | 0.4578 (0.3929, 0.5226) | <0.001 | 464/4,737 | 1.67 (1.33, 2.11) | <0.001 |
| Model 2 | 5,205 | −0.0098 (−0.0114, −0.0082) | <0.001 | 5,205 | 0.3242 (0.2652, 0.3832) | <0.001 | 458/4,668 | 1.50 (1.17, 1.92) | 0.002 | |
Model 1 adjusts for age, sex, and race; model 2 adjusts for model 1 adjustments and BMI, systolic blood pressure, antihypertensive medication, smoking status, heavy alcohol use, physical activity, estrogen use, prevalent atherosclerotic cardiovascular disease, prevalent HF, and eGFR. HR, hazard ratio.