Table 3.
Instrumental variable analysis for causal association of sCD14 with measures of insulin resistance
| Mendelian randomization results for sCD14 as endogenous regressor | |||||||
|---|---|---|---|---|---|---|---|
| Race | Outcome | Instrumental variables | N | First stage | Second stage | ||
| F | P value | F | P value | ||||
| White | QUICKI | rs5744455 (top SNP in whites) | 3,387 | 101.3 | <0.001 | 0.00 | 0.960 |
| White | HOMA2IR | rs5744455 (top SNP in whites) | 3,356 | 101.82 | <0.001 | 0.32 | 0.574 |
| White | QUICKI | rs778584 | 3,387 | 59.87 | <0.001 | 2.4 | 0.120 |
| White | HOMA2IR | rs778584 | 3,356 | 59.26 | <0.001 | 1.15 | 0.283 |
| White | QUICKI | rs4914 | 3,385 | 20.57 | <0.001 | 1.1 | 0.286 |
| White | HOMA2IR | rs4914 | 3,354 | 20.40 | <0.001 | 1.36 | 0.244 |
| Black | QUICKI | rs5744451 (top SNP in blacks) | 422 | 27.39 | <0.001 | 1.8 | 0.187 |
| Black | HOMA2IR | rs5744451 (top SNP in blacks) | 414 | 25.93 | <0.001 | 2.39 | 0.123 |