Skip to main content
. 2019 Aug 26;68(11):2131–2142. doi: 10.2337/db18-1278

Figure 2.

Figure 2

Fenofibrate treatment restored ECFC/CAC number and mitochondrial function in ECFC/CACs in diabetic mice. A: Representative FCM gating strategy for the identification of ECFC/CACs (CD34+, CD45−/dim, CD133+, VEGFR2+) in the BM. B: Representative FCM profiles showed ECFC/CAC number change in the BM of db/db mice (DB), db/db mice with fenofibrate chow for 12 weeks (DB-Feno), db/+ littermate CTR mice, and CTR mice with fenofibrate chow (CTR-Feno). C: ECFC/CAC numbers in the BM decreased in db/db mice (DB) and were restored by fenofibrate treatment (DB-Feno) (n = 6). D: ECFC/CAC numbers in the blood decreased in db/db mice (DB) and were restored by fenofibrate (DB-Feno) (n = 5). E and F: ∆Ψm was measured by FCM (n = 4). E: The percentage of ECFC/CACs with high ∆Ψm was decreased in the circulation of db/db mice (DB) compared with that in CTR mice (n = 4). F: Fenofibrate treatment (DB-Feno) elevated the percentage of high ∆Ψm ECFC/CACs in the circulation of db/db mice compared with db/db mice with regular chow (DB). All values are mean ± SEM. **P < 0.01; ****P < 0.001. FSC, forward light scatter; LinA, linear forward scatter area; LinH, linear forward scatter height; SSC, side scatter.