Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Sep 6;68(11):2143–2154. doi: 10.2337/db19-0271

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2019 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at http://www.diabetesjournals.org/content/license.

PMC Copyright notice

NSI-189 augments neurite outgrowth and mitochondrial function in adult rat DRG sensory neurons. A and B: Effect of NSI-189 on neurite outgrowth from normal neurons (n = 5–7 replicate cultures). C: Effect of NSI-189 on DRG neurons derived from a 3- to 4-month STZ-induced diabetic rat (n = 6–10 replicate cultures). D: Seahorse XF24 trace showing oxygen consumption rate (OCR) of neurons from diabetic rats treated for 24 h with 1.0 or 3.0 μmol/L NSI-189. The following drugs were added: oligomycin (oligo), carbonyl cyanide-4-(trifluoromethoxy)phenylhydrazone (FCCP), and rotenone + antimycin A (Rot+AA) . Basal respiration (E), maximal respiration (F), and spare respiratory capacity (G) derived from D (n = 6–7 replicate cultures). Data are mean ± SD. *P < 0.05, **P < 0.01 by one-way ANOVA, followed by the Dunnett post hoc test.