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. 2019 Sep 6;68(11):2143–2154. doi: 10.2337/db19-0271

Figure 6.

Figure 6

NSI-189 ameliorates CNS and PNS neuropathy in db/db mice. Hippocampal NeuN (A), PSD95 (B), synaptophysin (C), and BDNF (D) protein levels, and MNCV (E), paw tactile 50% PWT (F), and corneal subbasal plexus nerve length (G) after 24 weeks of diabetes, with NSI treatment for the last 16 weeks. C, control mice treated daily with vehicle; D, db/db mice treated daily with vehicle; DNSI, db/db mice treated daily with oral NSI-189. Data are mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001 by one-way ANOVA, followed by the Dunnett post hoc test (n = 8–10/group).