Table 1.

Pharmacokinetics parameters after intravenous or oral delivery of NSI-189 to normal mouse

	Dose (mg/kg)	Tmax (h)	Cmax (ng/mL)	AUC0–t (ng∗h/mL)
Intravenous delivery
Plasma	1	0.083	215	172
	3	0.083	858	625
	10	0.083	3,014	2,135
Brain	1	0.13	298	165
	3	0.13	654	522
	10	0.13	2,280	1,278
Oral delivery
Plasma	10	0.5	116	105
	30	0.25	270	420
Brain	10	0.5	78	258
	30	0.3	170	425