Table 2.
Impact of diabetes and NSI-189 on terminal systemic parameters in mice
| N | Body weight | Blood glucose | Blood HbA1c | Blood HbA1c | Deaths during study | |
|---|---|---|---|---|---|---|
| (g) | (mg/dL) | (%) | (mmol/mol) | |||
| Type 1: Prevention | ||||||
| Control + vehicle | 10 | 32.4 ± 4.7* | 153 ± 26*** | 3.1 ± 0.2*** | 10.1 ± 2.7*** | 0 |
| STZ + vehicle | 9 | 28.4 ± 3.0 | 562 ± 17 | 6.1 ± 0.2 | 43.6 ± 2.3 | 1 |
| STZ + insulin | 8 | 29.2 ± 2.2 | 215 ± 132*** | 4.0 ± 0.8*** | 19.9 ± 8.4*** | 2 |
| STZ + NSI-189 | 9 | 29.9 ± 2.2 | 567 ± 43 | 6.3 ± 0.7 | 45.9 ± 7.1 | 1 |
| Type 1: Intervention | ||||||
| Control + vehicle | 10 | 31.6 ± 2.2*** | 118 ± 12*** | ND | ND | 0 |
| STZ + vehicle | 10 | 25.9 ± 2.1 | 559 ± 47 | ND | ND | 0 |
| STZ + NSI-189 | 9 | 27.5 ± 1.7 | 589 ± 16 | ND | ND | 1 |
| Type 2: Prevention | ||||||
| WT + vehicle | 10 | 29.6 ± 1.7*** | 143 ± 24** | 4.1 ± 0.2*** | 21.3 ± 1.9*** | 0 |
| WT + NSI-189 | 10 | 29.6 ± 1.5*** | 161 ± 20** | 4.2 ± 0.2*** | 21.6 ± 1.8*** | 0 |
| db/db + vehicle | 10 | 62.6 ± 7.2 | 307 ± 180 | 5.7 ± 1.4 | 38.9 ± 15.7 | 0 |
| db/db + NSI-189 | 8 | 66.2 ± 2.9 | 189 ± 19* | 5.1 ± 0.9 | 31.8 ± 10.0 | 2 |
| Type 2: Intervention | ||||||
| WT + vehicle | 10 | 30.2 ± 1.2*** | 167 ± 9*** | ND | ND | 0 |
| db/db + vehicle | 10 | 54.8 ± 8.0 | 439 ± 61 | ND | ND | 0 |
| db/db + NSI-189 | 10 | 55.6 ± 5.3 | 483 ± 71 | ND | ND | 0 |
Data are mean ± SD. Statistical comparison by one-way ANOVA with the Dunnett post hoc test. ND, not determined.
*P < 0.05, **P < 0.01, ***P < 0.001 vs. vehicle-treated diabetic mice.