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Sarm1 gene deficiency attenuates intraepidermal nerve fiber loss in footpad skin of diabetic mice. Representative images of intraepidermal nerve fiber profiles (A) and the quantification of INFD (B) in wild-type (WT) and Sarm1−/− mice after 5-day injection with vehicle or STZ and for the subsequent 25 weeks. Scale bar, 35 μm; n = 4–6 for each group. C: The blood glucose levels of mice were detected before the measurement of INFD. n = 8 for each group. **P < 0.01; ***P < 0.001.
