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Schematic presentation of the signaling pathways involved in erinacine A–induced cell apoptosis in human DLD-1 cancer cells, and the effect of erinacine A on the activation of the JNK/p300/p50 NFκB pathways, which leads to TNFR, Fas, and FasL expression with the implications of histone H3K9K14ac (Acetyl Lys9/Lys14) in human DLD-1. Erinacine A triggered the apoptosis pathway through the inhibition of Bcl-2 and Bcl-XL and the Bax increase and activation of caspase-8, -3, and -9.
