Fig. 2.
Mechanisms of the benefits of neuroinflammation for myelin repair. Contributory mechanisms for remyelination include the production of several neurotrophic factors by all types of immune cells, the reduction of immune overactivity by growth factors produced by immune cells, the phagocytic clearance of inhibitory myelin debris and toxic substances such as Aβ, the removal of CSPGs that impede remyelination and axonal regeneration, the maintenance of iron homeostasis, and the regulation of lactate bioavailability