Table 3.
Geometric Mean, Ratio, Intra-Individual Variability, And 90% Confidence Intervals For Levocetirizine In Fasting And Fed Conditions
| Parameters | Fasting Condition (n=22) | Fed Condition (n=23) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Geometric Mean and Ratio | Intra-Individual Variability (%CV) | 90% CIs | Geometric Mean and Ratio | Intra-Individual Variability (%CV) | 90% CIs | |||||
| Generic Formulation | Branded Formulation | (Generic/Branded)% | Generic Formulation | Branded Formulation | (Generic/Branded)% | |||||
| Cmax (ng/mL) | 217.229 | 215.503 | 100.8 | 11.90 | 94.75–107.24 | 152.178** | 142.110## | 107.1 | 13.58% | 99.98–114.69 |
| AUC0–36h (h·ng/mL) | 1,717.378 | 1,722.742 | 99.7 | 4.90 | 97.17–102.27 | 1,486.410* | 1,467.359# | 101.3 | 5.11% | 98.71–103.96 |
| AUC0-∞ (h·ng/mL) | 1,782.428 | 1,786.390 | 99.8 | 5.16 | 97.13–102.50 | 1,541.563* | 1,524.338# | 101.1 | 5.47% | 98.36–103.98 |
Notes: *P<0.05, **P<0.01 for the generic formulation of levocetirizine under fed condition versus that under fasting condition. #p<0.05, ##p<0.01 for the branded formulation of levocetirizine under fed condition versus that under fasting condition.
Abbreviation: 90% CIs, 90% confidence intervals.