Schema model of SOS pathway regulated by Ca2+ under saline shock. Ca2+ signaling triggered by salt stress activate SOS3 causes interaction with SOS2. SOS3/SOS2 complex activates SOS1 by direct phosphorylation driven by SOS2 and result in Na+ efflux. Alternatively, SOS2 regulates vacuolar channels (CAX and NHX) and balance Na+ vacuolar sequestration. CAX: Vacuolar H+/Ca2+ antiporter, CBL: Calcineurin B-like protein, CIPK: CBL-interacting protein kinase, NHX: Vacuolar located Na+/H+ antiporters, SOS: Salt overly sensitive, SS: Salt stress. SRR: Sal responsive receptors.