Fig. 5.

Bench-to-bedside strategies for osteoporotic fracture. The most satisfactory bone healing depends on two pivotal factors: a good biological environment and appropriate mechanical loading for bone repair and homeostasis. Bench-to-bedside strategies, including management of hematomas and perioperative infections, anti-inflammation and regulation of bone resorption, and rigid fixation and mechanical loading enhancement would benefit the creation of the proper environment for fracture healing of osteoporotic bones. PRPs platelet-rich plasma, PRFs platelet-rich fibrin, rhPDGF-BB recombinant human platelet-derived growth factor-BB, TNF-α tumor necrosis factor alpha, IL-1 interleukin-1, RANKL receptor activator of nuclear factor kappa-B ligand, rhPTH recombinant human parathyroid hormone, PTHrP parathyroid hormone-related protein, BMPs bone morphogenetic proteins. “Red” refers to upregulation; “Green” refers to downregulation