Figure 3.

POMC methylation in obesity. The studies by Zhang et al., (2014) and Kuhnen et al. (2016), have shown that hypermethylation of transcription factor binding sites for Sp1 and P300 within POMC results in repressed gene expression. Sequences of the (a) mouse and (b) human POMC gene were obtained from Ensembl (GRCh38.p12 and GRCm38.p6 builds, respectively). The chromosome location, the transcriptional start site, intronic regions (pink or blue), exonic regions (bolded letters), and putative CpG sites (underlined) are indicated