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Typical pharmacological effects of NAS PAMs on GABAA receptor function at the whole-cell level. NAS at a modest, fixed concentration usually shift the GABA EC50 value to the left and increase the maximum GABA response, i.e., increase agonist efficacy. Because GABA is a lower efficacy agonist on δ-containing receptors than on γ2-containing receptors, NAS may have a somewhat larger effect on δ containing receptors.
