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. 2019 Sep 1;20(12):1416–1429. doi: 10.1080/15384047.2019.1647049

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Figure 8. — Apoptosis of SK-N-AS neuroblastoma cells is enhanced by treatment with Cetuximab and SH-4-54. Parental SK-N-AS cells, SK-N-AS cells infected with a scrambled shRNA, or SK-N-AS cells depleted of UBE4B, were treated with vehicle (blue bars), SH-4-54 (5 μM, red bars) Cetuximab (2 μM, green bars), or a combination of Cetuximab and SH-4-54 (purple bars). Caspase-3/7 activity was assessed with CellEvent detection reagent and phase contrast microscopy to quantify cell numbers. Percent apoptotic cells (the ratio of fluorescent cells/total cell count) was significantly greater in UBE4B-depleted and parental cells treated with the drug combination compared to SK-N-AS cells treated with vehicle, or cells treated with either Cetuximab or SH-4-54 alone. The mean ±S.E.M. is displayed for each condition and reflects data collected from three independent trials. Comparisons were made using ANOVA with post hoc Dunnett multiple comparison test. * denotes p < .05, ** denotes p < .01, *** denotes p < .001.