Post-treatment pregnancies by trial. GnRHa, gonadotropin-releasing hormone agonists; IRR, incidence rate ratio; OPTION, Ovarian Protection Trial in Oestrogen Non-responsive Premenopausal Breast Cancer Patients Receiving Adjuvant or Neo-adjuvant Chemotherapy; POEMS Prevention Of Early Menopause Study; PROMISE-GIM6, PRevention Of Menopause Induced by chemotherapy: a Study in Early breast cancer patients—Gruppo Italiano Mammella 6; pts, patients.