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. 2019 Jul 25;7:21. doi: 10.1038/s41413-019-0060-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Bone features of ΔEpoR_E mice with lack of EPOR signaling in non-erythroid cells. a Micro-CT generated images of trabecular bone of 11-week-old male wild-type (wt) and ΔEpoR_Emice. b–c Femurs of 11-week-old male and female ΔEpoR_E mice and age matched wt mice were analyzed using micro-CT. Quantitation of trabecular BMD, BV/TV, number, and spacing of trabecular bone of male (b) and female ΔEpoR_E mice (c) and controls (n = 4/group). d–h EPO induced changes in bones of 8-week-old wild-type (wt) and ΔEpoR_E mice with Epor deletion in non-erythroid cells. d 3D images of trabecular bones of wt and ΔEpoR_E mice receiving 1 200 IU·kg^–1 of EPO for 10 days. Quantification of trabecular parameters including trabecular BMD (e), BV/TV (f), trabecular number (g), and trabecular spacing (h). (n = 5/group, *P < 0.05, **P < 0.01, ***P < 0.001)