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. 2019 Oct 10;17(10):e3000477. doi: 10.1371/journal.pbio.3000477

Fig 4. Key role of striatal NF1 in motor learning.

Fig 4

(A) Scheme of NF1 deletion from MSNs and accelerating rotarod paradigm. (B) Performance of Nf1flx/flx and Nf1flx/flxRgs9cre mice on the accelerating rotarod. n = 14 mice/group, two-way RM ANOVA. (C) Percentage of mice able to reach maximal speed. (D) Learning rate of Nf1flx/flx and Nf1flx/flxRgs9cre mice on the accelerating rotarod. Student t test. (E) Grip strength and (F) wire hang for Nf1flx/flx and Nf1flx/flxRgs9cre mice. n = 9 mice/group. (G) Time course of the terminal speed (trial 4) over 10 days of consecutive training on the accelerating rotarod for Nf1flx/flx and Nf1flx/flxRgs9cre mice. n = 8–13 mice/group, two-way RM ANOVA. (H) Probability of reaching maximal speed over the 10 days of training on the accelerating rotarod. Data are represented as mean ± SEM. *P < 0.05, ***P < 0.001. Underlying data for this figure can be found in S1 Data. MSN, medium spiny neuron; NF1, neurofibromin 1; RM-ANOVA, repeated measures analysis of variance.