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. 2019 Oct 10;17(10):e3000477. doi: 10.1371/journal.pbio.3000477

Fig 7. Chemogenetic and pharmacological rescue of motor deficits associated with NF1 deficiency.

Fig 7

(A) Scheme and Image of Nf1flx/flxD2cre mice bilaterally injected in the striatum with AAV-DIO-rM3Gs. Mouse graphic was adapted from [44]. (B) Quantification of striatal cAMP levels of Nf1flx/flxD2cre bilaterally injected with AAV-DIO-rM3Gs or DIO-mcherry upon CNO administration. n = 6 mice/group. (C) Increase in performance and (D) learning rate on the accelerating rotarod of DIO-rM3Gs mice compared with DIO-mcherry mice following CNO injection in Nf1flx/flxD2cre mice. n = 6–7 mice/group. (E) Quantification of striatal cAMP levels in Nf1flx/flx and Nf1flx/flxRgs9cre treated with rolipram. (F) Performance and (G) learning rate on the rotarod task for Nf1flx/flx and Nf1flx/flxRgs9cre mice treated with rolipram. n = 7–10 mice/group. Two-way RM ANOVA. *P < 0.05, **P < 0.01. Data are represented as mean ± SEM. Underlying data for this figure can be found in S1 Data. DIO, double-floxed inverted open reading frame; NF1, neurofibromin 1; RM-ANOVA, repeated measures analysis of variance; Rol, rolipram; Veh, vehicle.