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. 2019 Oct 10;13(10):e0007764. doi: 10.1371/journal.pntd.0007764

Fig 4. Gene expression in whole blood from RR temporal stages.

Fig 4

(A) Identification of RR whole blood subtype gene modules. WGCNA eigengene modules correlated to at least one RR temporal subtype (p ≤ 0.05). Red indicates a positive correlation, and green indicates an inverse correlation. Module eigengenes, as well as the corresponding number of genes in each module, are labeled on the y axis, and RR temporal stages are labeled on the x axis. BR (before reaction), RR (reaction) and AT (after reaction treatment). (B) Integration of WGCNA gene modules with cell-type-specific gene signatures. For the two significant modules derived from WGCNA, enrichment for MDM IFN-β and IFN-γ specific downstream genes (2h, 6h and 24h) were calculated and displayed in a heatmap of Z scores. Hypergeometric analyses were performed to determine enrichment p-value. * p<0.001.