Table 2.
Treatment-related toxicities
| Toxicity | Grade 1 | Grade 2 | Grade 3 | Grade 4 |
|---|---|---|---|---|
| Fatigue | 5 | 6 | 1 | 0 |
| Rash - acneiform, maculopapular | 13 | 6 | 2 | 0 |
| Dry skin | 7 | 1 | 0 | 0 |
| Skin infection/paronychia | 1 | 2 | 1 | 0 |
| Dehydration | 0 | 0 | 1 | 0 |
| Anorexia | 1 | 1 | 1 | 0 |
| Thromboembolic event | 0 | 6 | 0 | 0 |
| Anemia | 8 | 4 | 2 | 0 |
| Lymphopenia | 11 | 9 | 1 | 0 |
| Leukopenia/neutropenia | 14 | 9 | 0 | 0 |
| Thrombocytopenia | 7 | 0 | 1 | 0 |
| Nausea | 5 | 2 | 0 | 0 |
| Vomiting | 4 | 1 | 0 | 0 |
| Diarrhea | 4 | 2 | 0 | 0 |
| Constipation | 2 | 0 | 0 | 0 |
| Dry mouth/mucositis | 4 | 1 | 0 | 0 |
| Transaminase elevations (ALT/AST) | 7 | 1 | 0 | 0 |
| Hyperbilirubinemia | 1 | 1 | 0 | 0 |
| Renal insufficiency | 1 | 0 | 1 | 0 |
| Hypocalcemia | 6 | 1 | 0 | 0 |
| Hypokalemia | 6 | 1 | 2 | 1 |
| Hypomagnesemia | 8 | 2 | 1 | 1 |
| Hypophosphatemia | 4 | 1 | 1 | 0 |
| Edema of extremities | 2 | 2 | 0 | 0 |
| Fever | 2 | 0 | 0 | 0 |
| Infection | 1 | 2 | 2 | 0 |
| Dyspnea | 0 | 3 | 0 | 0 |