. Author manuscript; available in PMC: 2019 Oct 22.

Published in final edited form as: Breast Cancer Res Treat. 2016 May 4;157(2):351–361. doi: 10.1007/s10549-016-3814-z

Table 6.

Stratification of women into low, intermediate, and high 10-year risk for subsequent metastatic/regional cancer

Risk category	Definition	Prevalence in cohort %^†	10-year risk of met/reg cancer % (95 % CI)
Lowest	p16⁻ and detected by mammogram	51	1.2 (1.1–1.3)
Low	p16⁻ and detected by palpation; or p16⁺COX-2⁺ER⁺ERBB2⁻; or p16⁺COX-2⁻	42	4.3 (4.0–4.7)
Intermediate	p16⁺COX-2⁺ER⁻ERBB2⁻; or p16⁺COX-2⁺ER⁺ERBB2⁺	4	12.2 (9.9–15.3)
High	p16⁺COX-2⁺ER⁻ERBB2⁺	3	22.5 (13.8–48.1)

^†

Average prevalence estimated among 2500 cohorts of 1490 women with missing measures imputed as described in the statistical section