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. 2019 Oct 22;8:e51109. doi: 10.7554/eLife.51109

Figure 6. The role of ICP4 in Pol II loss on host promoters.

Figure 6.

MRC5 cells were (A-B) uninfected or infected with n12 or WT HSV-1 and harvested prior to genome replication or C-D) infected with tsKos and grown at permissive conditions (P), shifted up from permissive to nonopermissive conditions at four hpi (S), or nonpermissive conditions (N). (A–D) ChIP-Seq for Pol II was performed. Data was aligned to the human genome (hg38) and normalized for cellular genome sampling. ChIP-Seq data was aligned to cellular promoters + /- 1 kilobase from TSS. The average signal for each condition plotted as a line graph.