Database or resource	Search strategy
CENTRAL (the Cochrane Library) (www.cochranelibrary.com/)	ADVANCED SEARCH ‐ SEARCH MANAGER FORM #1 cystic next fibros* #2 MeSH descriptor: [Cystic Fibrosis] this term only #3 MeSH descriptor: [Cystic Fibrosis Transmembrane Conductance Regulator] this term only #4 cftr #5 fibrocystic and pancrea* #6 mucoviscido* #7 #1 or #2 or #3 or #4 or #5 or #6 #8 rhinitis or sinusitis or rhinosinusitis #9 MeSH descriptor: [Sinusitis] explode all trees #10 #8 or #9 #11 #7 and #10
PubMed (www.ncbi.nlm.nih.gov/pubmed)	(Cystic Fibrosis OR mucoviscidosis OR cystic fibrosis transmembrane conductance regulator OR cftr) AND (rhinitis OR sinusitis OR rhinosinusitis) AND (randomized controlled trial [pt] OR controlled clinical trial [pt] OR randomized [tiab] OR placebo [tiab] OR drug therapy [sh] OR randomly [tiab] OR trial [tiab] OR groups [tiab] NOT (animals [mh] NOT humans [mh]))
Embase Ovid	(Cystic Fibrosis OR mucoviscidosis OR cystic fibrosis transmembrane conductance regulator OR cftr) AND (rhinitis OR sinusitis OR rhinosinusitis) AND (randomized controlled trial [pt] OR controlled clinical trial [pt] OR randomized [tiab] OR placebo [tiab] OR drug therapy [sh] OR randomly [tiab] OR trial [tiab] OR groups [tiab] NOT (animals [mh] NOT humans [mh]))
ClinicalTrials.gov (www.clinicaltrials.gov/)	RECRUITMENT STATUS: All studies CONDITION OR DISEASE: cystic fibrosis OTHER TERMS: rhinitis OR sinusitis OR rhinosinusitis
WHO ICTRP (apps.who.int/trialsearch/Default.aspx)	SEARCH 1: cystic fibrosis AND rhinitis SEARCH 2: cystic fibrosis AND sinusitis SEARCH 3: cystic fibrosis AND rhinosinusitis
EU Clinical Trials Register (www.clinicaltrialsregister.eu/)	(cystic fibrosis) AND (rhinitis OR sinusitis OR rhinosinusitis)