Table 3.
Genotype distributions and allele frequencies of CD44 polymorphisms between disease groups and controls
| Polymorphisms |
HC (n = 210) |
CHB (n = 96) |
LC (n = 96) |
HCC (n = 204) |
CHB vs HC | LC vs HC | HCC vs HC | |||
|---|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | |||||
| rs8193 | ||||||||||
| Genotypes | ||||||||||
| CC | 66 (31.4) | 37 (38.5) | 36 (37.5) | 61 (29.9) | 1.00ref | 1.00ref | 1.00ref | |||
| CT | 103 (49.1) | 44 (45.8) | 46 (47.9) | 112 (54.9) | 0.649 (0.351‐1.199) | .167 | 0.906 (0.520‐1.578) | .728 | 1.173 (0.748‐1.838) | .488 |
| TT | 41 (19.5) | 15 (15.7) | 14 (14.6) | 31 (15.2) | 0.740 (0.328‐1.670) | .469 | 0.685 (0.322‐1.458) | .327 | 0.809 (0.446‐1.467) | .485 |
| Allele | ||||||||||
| C | 235 (55.9) | 118(61.4) | 118(61.4) | 234 (57.4) | 1.00ref | 1.00ref | 1.00ref | |||
| T | 185 (44.1) | 74 (38.6) | 74 (38.6) | 174 (42.6) | 0.821 (0.553‐1.219) | .328 | 0.843 (0.588‐1.207) | .350 | 0.940 (0.710‐1.246) | .667 |
| Dominant model | ||||||||||
| CC | 66 (31.4) | 37 (38.5) | 36 (37.5) | 61 (29.9) | 1.00ref | 1.00ref | 1.00ref | |||
| CT + TT | 144 (68.6) | 59 (61.5) | 60 (62.5) | 143 (70.1) | 0.672 (0.377‐1.197) | .177 | 0.843 (0.499‐1.424) | .523 | 1.068 (0.696‐1.637) | .763 |
| Recessive model | ||||||||||
| CC + CT | 169 (80.5) | 81 (84.3) | 82 (85.4) | 173 (84.8) | 1.00ref | 1.00ref | 1.00ref | |||
| TT | 41 (19.5) | 15 (15.7) | 14 (14.6) | 31 (15.2) | 0.955 (0.459‐1.986) | .901 | 0.726 (0.366‐1.438) | .358 | 0.733 (0.433‐1.239) | .246 |
| rs10836347 | ||||||||||
| Genotypes | ||||||||||
| CC | 98 (46.7) | 40 (41.7) | 36 (37.5) | 73 (35.8) | 1.00ref | 1.00ref | 1.00ref | |||
| CT | 90 (42.9) | 48 (50) | 40 (41.7) | 99 (48.5) | 0.304 (0.089‐1.039) | .057 | 1.306 (0.619‐2.757) | .484 | 1.406 (0.784‐2.251) | .253 |
| TT | 22 (10.4) | 8 (8.3) | 20 (20.8) | 32 (15.7) | NA | NA | NA | |||
| Allele | ||||||||||
| C | 286 (68.1) | 128(66.7) | 112(58.3) | 245 (60.0) | 1.00ref | 1.00ref | 1.00ref | |||
| T | 134 (31.9) | 64 (33.3) | 80 (41.7) | 163 (40.0) | 0.318 (0.095‐1.065) | .063 | 1.282 (0.624‐2.632) | .499 | 1.372 (0.782‐2.409) | .271 |
| rs13347 | ||||||||||
| Genotypes | ||||||||||
| CC | 98 (46.7) | 40 (41.7) | 36 (37.5) | 73 (35.8) | 1.00ref | 1.00ref | 1.00ref | |||
| CT | 90 (42.9) | 48 (50) | 40 (41.7) | 99 (48.5) | 1.225 (0.688‐2.183) | .490 | 1.282 (0.737‐2.230) | .379 | 1.626 (1.057‐2.500) | .027 |
| TT | 22 (10.4) | 8 (8.3) | 20 (20.8) | 32 (15.7) | 1.033 (0.382‐2.795) | .948 | 2.601 (1.242‐5.447) | .011 | 1.965 (1.043‐3.702) | .037 |
| Allele | ||||||||||
| C | 286 (68.1) | 128(66.7) | 112(58.3) | 245 (60.0) | 1.00ref | 1.00ref | 1.00ref | |||
| T | 134 (31.9) | 64 (33.3) | 80 (41.7) | 163 (40.0) | 1.085 (0.720‐1.634) | .697 | 1.588 (1.102‐2.288) | .013 | 1.461 (1.091‐1.956) | .011 |
| Dominant model | ||||||||||
| CC | 98 (46.7) | 40 (41.7) | 36 (37.5) | 73 (35.8) | 1.00ref | 1.00ref | 1.00ref | |||
| CT + TT | 112 (53.3) | 56 (58.3) | 60 (62.5) | 131 (64.2) | 1.192 (0.683‐2.079) | .536 | 1.551 (0.930‐2.587) | .093 | 1.697 (1.130‐2.549) | .011 |
| Recessive model | ||||||||||
| CC + CT | 188 (89.4) | 88 (91.7) | 76 (79.2) | 172 (84.3) | 1.00ref | 1.00ref | 1.00ref | |||
| TT | 22 (10.4) | 8 (8.3) | 20 (20.8) | 32 (15.7) | 0.927(0.361‐2.381) | .874 | 2.304(1.162‐4.568) | .017 | 1.524 (0.844‐2.752) | .162 |
Abbreviations: CHB, chronic HBV; HC, healthy controls; HCC, hepatocellular carcinoma; LC, liver cirrhosis.