Table 4.
Correlations between progression‐free survival (PFS) and various clinicopathological factors
| Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|
| Hazard ratio | 95% CI | P‐value | Hazard ratio | 95% CI | P‐value | |
| Age (>60 y) | 1.242 | 0.775‐1.992 | 0.368 | |||
|
Body mass index (<18.5 or >25 kg/m2) |
1.008 | 0.594‐1.711 | 0.976 | |||
|
Location of primary tumor (Right‐sided colon) |
1.554 | 0.908‐2.660 | 0.108 | |||
|
Histological type (Poorly, mucinous) |
2.269 | 1.361‐3.784 | 0.002 | 2.671 | 1.564‐4.562 | <0.001 |
| Detection of unresectable tumor (metachronous) | 0.556 | 0.320‐0.968 | 0.038 | |||
| Peritoneal dissemination (Yes) | 2.058 | 1.239‐3.417 | 0.005 | |||
| Number of organs affected by metastasis (≥2) | 1.907 | 1.146‐3.176 | 0.013 | |||
| RAS/BRAF gene mutations (Yes) | 1.190 | 0.673‐2.106 | 0.550 | |||
| Molecular‐targeted therapy (Yes) | 0.727 | 0.452‐1.167 | 0.186 | |||
| CEA (>5 ng/mL) | 1.523 | 0.854‐2.719 | 0.154 | |||
| CA19‐9 (>37 U/mL) | 2.344 | 1.409‐3.898 | 0.001 | 2.440 | 1.434‐4.149 | 0.001 |
| Hemoglobin (<115 g/L) | 5.299 | 2.820‐9.955 | <0.001 | 4.761 | 2.523‐8.986 | <0.001 |
| AGR ≤ 1.40 | 2.140 | 1.322‐3.465 | 0.002 | |||
| FAR > 10.63 | 1.911 | 1.143‐3.197 | 0.014 | |||
| PGR ≤ 5.44 | 2.425 | 1.458‐4.032 | 0.001 | |||
| FPR > 18.49 | 1.786 | 1.108‐2.880 | 0.017 | |||