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. 2019 Jul 5;33(8):e22962. doi: 10.1002/jcla.22962

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© 2019 The Authors. Journal of Clinical Laboratory Analysis Published by Wiley Periodicals, Inc.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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The effect of OLC8 on GC was mediated by IL‐11. (A) Expression of IL‐11 mRNA in AGS cells transfected with lentiviral control plus scramble shRNA control (control + ShCtrl), lentivirus containing OLC8 plus ShCtrl (OLC8 + ShCtrl), the OLC8 mutant plus ShCtrl (OLC8‐Mut + ShCtrl), or lentivirus containing OLC8 plus ShIL‐11 (OLC8 + ShIL‐11). Efficiency of ShIL‐11 knockdown was displayed as inset. ShIL‐11#2 showed higher efficiency and therefore denoted ShIL‐11. (B) The level of OLC8 in AGS cells. The color labels were the same as (A). (C) Migration assay for different AGS cells as specified. (D) The quantification was shown for (C). (E) AGS xenograft tumors with combinatorial OLC8, OLC8‐Mut, or IL‐11 transfection as specified. (F) Quantification of (E) as measured via tumor weight. **P < 0.01