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. 2019 Oct 22;11:148. doi: 10.1186/s13148-019-0736-8

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — ZIC2 immunostaining in > 12,000 micro-arrayed PCa cases. a Examples of negative (no nuclear staining, upper panels) and strong staining (lower panels). b Association between ZIC2 immunostaining results and the ERG-status determined by IHC and FISH analysis. c Association between ZIC2 immunostaining and deletions of 10q23 (PTEN), 6q15 (MAP 3 K7), 5q21 (CHD1) and 3p13 (FOXP1) for all cancers (a), ERG fusion-negative (b) and ERG fusion-positive subset (c) according to ERG-IHC analysis. d Kaplan-Meier curves for the relationship of ZIC2 immunostaining with PSA recurrence-free survival in all cancers (a), in ERG fusion-negative cancers (b), in ERG fusion-positive cancers (c), in PTEN normal cancers (d) and in PTEN deleted cancers (e). Log-rank p values