Table 2.
Genotype distributions of five SNPs between cases and controls
| Gene | SNPs | Control, n(%) | COPD, n(%) | PTB, n(%) | ORCOPD(95% CI)a | P COPD | ORPTB(95% CI)a | P PTB |
|---|---|---|---|---|---|---|---|---|
| TLR4 | rs10759932c | |||||||
| TT | 885 (51.6) | 107 (72.8) | 722 (45.7) | 1 | 1 | |||
| TC | 675 (39.4) | 35 (23.8) | 697 (44.1) | 0.42 (0.28–0.64) | < 0.001b | 1.28 (1.11–1.49) | 0.001b | |
| CC | 154 (9.0) | 5 (3.4) | 161 (10.2) | 0.24 (0.09–0.63) | 0.004b | 1.26 (0.98–1.62) | 0.068 | |
| T | 2445 (71.3) | 249 (84.7) | 2141 (67.8) | 1 | 1 | |||
| C | 983 (28.7) | 45 (15.3) | 1019 (32.2) | 0.45 (0.32–0.62) | < 0.001b | 1.18 (1.07–1.32) | 0.002b | |
| rs2737190c | ||||||||
| AA | 630 (37.0) | 91 (63.2) | 518 (32.6) | 1 | 1 | |||
| AG | 781 (45.9) | 34 (23.6) | 840 (52.9) | 0.32 (0.21–0.49) | < 0.001b | 1.30 (1.11–1.52) | 0.001b | |
| GG | 291 (17.1) | 19 (13.2) | 231 (14.5) | 0.42 (0.24–0.72) | 0.002b | 0.94 (0.76–1.16) | 0.563 | |
| A | 2041 (60.0) | 216 (75.0) | 1876 (59.0) | 1 | 1 | |||
| G | 1363 (40.0) | 72 (25.0) | 1302 (41.0) | 0.50 (0.38–0.66) | < 0.001b | 1.04 (0.94–1.15) | 0.443 | |
| rs7873784c | ||||||||
| GG | 1426 (83.3) | 105 (72.9) | 1310 (83.1) | 1 | 1 | |||
| GC | 275 (16.1) | 33 (22.9) | 256 (16.2) | 1.55 (1.00–2.42) | 0.052 | 1.02 (0.84–1.23) | 0.860 | |
| CC | 11 (0.6) | 6 (4.2) | 11 (0.7) | 16.72 (4.29–65.12) | < 0.001b | 1.27 (0.54–3.00) | 0.591 | |
| G | 3127 (91.3) | 243 (84.4) | 2876 (91.2) | 1 | 1 | |||
| C | 297 (8.7) | 45 (15.6) | 278 (8.8) | 1.95 (1.39–2.74) | < 0.001b | 1.02 (0.86–1.21) | 0.841 | |
| rs11536889c | ||||||||
| GG | 1013 (59.0) | 47 (31.1) | 953 (60.2) | 1 | 1 | |||
| GC | 611 (35.6) | 67 (44.4) | 535 (33.8) | 2.68 (1.78–4.05) | < 0.001b | 0.97 (0.84–1.13) | 0.713 | |
| CC | 93 (5.4) | 37 (24.5) | 94 (5.9) | 8.65 (5.04–14.82) | < 0.001b | 1.10 (0.81–1.49) | 0.559 | |
| G | 2637 (76.8) | 161 (53.3) | 2441 (77.1) | 1 | 1 | |||
| C | 797 (23.2) | 141 (46.7) | 723 (22.9) | 2.90 (2.28–3.68) | < 0.001b | 0.98 (0.87–1.10) | 0.730 | |
| rs10983755c | ||||||||
| GG | 904 (52.5) | 51 (33.8) | 806 (50.7) | 1 | 1 | |||
| GA | 679 (39.4) | 70 (46.4) | 644 (40.5) | 1.90 (1.28–2.82) | 0.002b | 1.07 (0.92–1.24) | 0.366 | |
| AA | 139 (8.1) | 30 (19.9) | 139 (8.7) | 4.27 (2.49–7.31) | < 0.001b | 1.09 (0.84–1.41) | 0.533 | |
| G | 2487 (72.2) | 172 (57.0) | 2256 (71.0) | 1 | 1 | |||
| A | 957 (27.8) | 130 (43.0) | 922 (29.0) | 1.96 (1.55–2.50) | < 0.001b | 1.06 (0.95–1.18) | 0.270 | |
aOR odds ratio, CI confidence interval; adjusted for age, sex, smoking and drinking; bsignificant after the Bonferroni correction for multiple comparisons. cwith missing values