Table 2.
Multivariate analysesa of predictive value of early MRI changes for later radiographic changes
Change from baseline to month 1 | Change from baseline to month 3 | ||||||
---|---|---|---|---|---|---|---|
Change from baseline to month 12 | RAMRIQ synovitis | RAMRIQ osteitis | RAMRIS erosions | RAMRIQ synovitis | RAMRIQ osteitis | RAMRIS erosions | |
Total radiographic progressionb | Estimate | 0.0002 | 0.645 | 0.777 | 0.0001 | 0.867 | 0.434 |
p value | 0.148 | 0.002 | 0.043 | 0.407 | 0.001 | 0.073 | |
Radiographic erosion progression | Estimate | 0.0001 | − 0.043 | 0.590 | 0.0001 | − 0.001 | 0.425 |
p value | 0.040 | 0.705 | 0.007 | 0.145 | 0.996 | 0.001 | |
Radiographic JSN progression | Estimate | 0.0000 | 0.688 | 0.187 | 0.0000 | 0.868 | 0.009 |
p value | 0.647 | < 0.001 | 0.409 | 0.907 | < 0.001 | 0.954 |
aBased on multivariate linear regression analysis
bAssessed by mTSS
JSN joint space narrowing, MRI magnetic resonance imaging, mTSS modified Total Sharp Score, RA rheumatoid arthritis, RAMRIQ automated quantitative RA MRI assessment system, RAMRIS RA MRI scoring system