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. 2019 Oct 21;17:169. doi: 10.1186/s12957-019-1706-5

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© The Author(s). 2019

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig 6 — Publication bias detected by funnel plots. The funnel plots showed the HR associated with MSI in included studies of different subgroups. a Overall survival (OS) for stage III RCT studies. b Disease-free survival (DFS) for stage III RCT studies. c OS for stage III retrospective studies. d DFS for stage III retrospective studies. e Disease-specific survival (DSS) for stage III retrospective studies. f OS for stage IV retrospective studies. g DFS for stage IV retrospective studies