Table 3.

Parameters of the Intensive Control Insulin–Nutrition–Glucose physiological model (Eqs. 1–3)

$p_G$	Non-insulin-mediated glucose clearance
${\alpha }_G$	Saturation of insulin-mediated glucose uptake
$\mathit{EGP}$	Endogenous Glucose Production (hepatic)
$\mathit{CNS}$	Glucose uptake by Central Nervous System
$V_G$	Glucose distribution volume
$n_K$	Kidney clearance of insulin
$n_L$	Liver clearance of insulin
${\alpha }_I$	Saturation of hepatic insulin clearance
$n_I$	Insulin diffusion between plasma and interstitium
$n_C$	Cellular degradation of internalised insulin
$x_L$	Fractional first pass hepatic insulin clearance from portal vein
$V_I$	Insulin distribution volume
$u_{\mathit{ex}}\left(t\right)$	Exogenous insulin
$u_{\mathit{en}}\left(G\right)$	Endogenous insulin