Table 2.
Sample (included in analysis) | Exposure type | Experimental conditions, exposure duration and blinding status | Outcome measure | Result | |
---|---|---|---|---|---|
VDU | |||||
Andersson et al. [59] | 17 IEI-EMF | VDU, MF: 245 nT (5 Hz – 2 kHz) and 19 nT (2 kHz – 400 kHz); EF: 7 V/m (5 Hz – 2 kHz) and 10 V/m (2 kHz – 400 kHz) |
Before and after cognitive behavioural treatment: 1 exposure session and 1 sham session, each 30 min; sessions were separated by at least 1 week; double-blind study |
Global rating of symptoms: assigned score on a 100-mm visual analogue scale (VAS) | No statistically significant effect of exposure |
Flodin et al. [60] | 15 IEI-EMF | Cathode ray tube (VDU or TV), MF: 5–2000 Hz mean of 342 nT, 2–400 kHz mean of 36 nT; EF: 5–2000 Hz mean of 288 V/m, 2–400 kHz mean of 6.2 V/m |
2 exposure sessions to the same signal, 2 sham sessions, each up to 1 h; sessions were separated by 2–32 days; double-blind study |
Chosen items from a questionnaire consisting of at least 29 symptoms | No statistically significant effect of exposure |
Lonne-Rahm et al. [61] |
24 IEI-EMF, 24 controls (12 IEI-EMF and 12 controls in each of two experiments that where combined for analysis) |
VDU, MF: 198 nT (5 Hz – 2 kHz) and 18 nT (2 kHz – 400 kHz); EF: 12 V/m (5 Hz – 2 kHz) and 10 V/m (2 kHz – 400 kHz) |
4 different exposure sessions: VDU “on” with stressor (visual test combined with calculations during a limited time period), VDU “off” with stressor, VDU “on” without stressor, VDU “off” without stressor, each 30 min; sessions were separated by 1 week; double-blind study |
Assigned scores on a VAS for rating the severity of facial skin symptoms, stress level, tiredness | No statistically significant effect of exposure |
Oftedal et al. [53] | 20 IEI-EMF |
VDU; static EF: − 2 – 9.5 kV/m, ELF EF: 2–12 V/m, VLF EF: 0.3–10.5 V/m |
1 exposure session without filter, 1 exposure session with inactive filter, 1 exposure session with active filter, each session lasted 2 weeks; symptom registration each day in week 2 of each session; double-blind study |
Assigned scores on a 10-interval scale for rating the severity of 7 categories of facial skin symptoms, 1 additional category for “other” symptoms | Symptoms less pronounced with active filters, small significant effect for sensations of tingling, itching, pricking (p = 0.03); no statistically significant effect for the 6 other groups of skin symptoms |
Oftedal et al. [62] | 38 IEI-EMF |
VDU; ELF EF: 0–20 V/m, VLF EF: 0.05–1 V/m |
1 exposure session without filter, 1 exposure session with inactive filter, 1 exposure session with active filter, each session lasted 3 months; symptom registration each day in week 4 and in the last week of each session; double-blind study |
Assigned scores on a 10-interval scale for rating the severity of 13 symptoms (skin: 4 symptoms, eye: 5 symptoms, nervous system: 4 symptoms) | No statistically significant effect of exposure |
Swanbeck and Bleeker [63] | 30 IEI-EMF | VDU; static EF: VDU-A: 0.2 kV/m, VDU-B: 30 kV/m; MF (1–300 kHz): VDU-A: 50 nT, VDU-B: 800 nT, alternating EF: both VDUs about 60 V/m |
1 exposure session with VDU-A, 1 exposure session with VDU-B, each 3 h; sessions were separated by 1 day; double-blind study |
Report of any skin symptoms experienced during a trial | No effect of exposure, concluded without statistical analysis |
ELF | |||||
Kim et al. [64] | 15 IEI-EMF, 16 controls | 60 Hz MF, 12.5 μT at the subjects’ head |
1 exposure session, 1 sham session, each 31 min; sessions were separated by at least 1 day; double-blind study |
Assigned scores on a 4-point scale [40] for rating the severity of 8 symptoms (throbbing, itching, warmth, fatigue, headache, dizziness, nausea, palpitations) | No statistically significant effect of exposure |
McCarty et al. [52] | 1 IEI-EMF | 60 Hz EF, average field of about 300 V/m around the head, less than 50 kV/m around the body |
1 condition with alternating 100 ms “field on”-“field off”-pulses during 100 s, 1 condition with 100 s continuous exposure, 1 sham condition, test 1: “on-off” and the sham condition repeated 10 times; test 2: all conditions repeated 5 times; next trial delayed until subject reported that symptoms had abated; double-blind study |
Verbal report of any symptoms experienced during a trial, questioned in interview | Statistically significant more severe symptoms reported in trials during pulsed exposure (p < 0.05), but not during continuous exposure |
Szemersky et al. [65] | 49 IEI-EMF, 57 controls | 50 Hz MF, exposed arm: 500 μT, other body parts: 1.14 μT |
10 exposure trials, 10 sham trials, each 1 min; trials were separated by 30 s; double-blind study |
Assigned scores on a 4-point scale for rating the severity of 15 symptoms (nervous system: 4 symptoms; visceral functions: 3 symptoms; sensations in the exposed hand: 8 symptoms), 1 additional category for “other” symptoms | No statistically significant effect of exposure |
Toomingas [66] | 1 IEI-EMF | 50 Hz MF, 34 or 100 μT |
Exposure trials at 2 different intensities and for a duration of either 1 or 10 s, sham trials for either 1 or 10 s, each condition repeated 24 times; interval between trials not reported; single-blind study |
Verbal report of any symptoms experienced during a trial | No effect of exposure, concluded without statistical analysis |
Trimmel and Schweiger [55] | 36 IEI-EMF, 30 controls | 50 Hz MF, 1 mT in the head area |
Each participant took part in 2 of the following sessions: session with EMF + noise, sham session (noise only), control session without noise and without EMF, each 1 h; sessions were separated by 1 h; double-blind study |
Assigned levels in the “Befindlichkeitsskala” questionnaire [67] for rating mood | More discomfort during EMF + noise compared to noise alone condition across all participants (p < 0.05). No statistically significant effect for each group analyzed separately |
Wenzel et al. [68] |
3 IEI-EMF, 7 controls |
50 Hz MF, 96 mT |
1st protocol: 25 min “field on”, 25 min “field off”; 2nd protocol: every 5 min “field on” and “field off” for a total duration of 50 min; no interval between conditions; double-blind study |
Verbal report of any symptoms experienced during a trial | No effect of exposure, concluded without statistical analysis |
RF | |||||
Augner et al. [56] | 8 IEI-EMF, 49 controls | Environmental, mainly 900 MHz GSM downlink signal, low: 5.2 μW/m2, medium: 153.6 μW/m2, high: 2126.8 μW/m2 |
Each participant allocated to 1 of 3 exposure scenarios with different combinations of five 50-min sessions with low, medium or high exposure level; interval of 5 min between each session; double-blind study |
Assigned scores on a 5-point scale for rating the severity of 3 items of well-being (good mood, alertness, calmness) from The Multi-Dimensional Well-Being questionnaire (MDBF) [69] | Main effects of exposure (all participants): Less psychological arousal (i.e., significantly calmer) with scenarios including high and medium exposure levels (p = 0.042). No statistically significant effects for other factors of well-being (good mood and alertness). No statistically significant interaction between exposure and group of participants (IEI-EMF or controls) |
Barth [70] | 1 IEI-EMF | Mobile phone (no information about exposure level, only that the mobile phone was switched “on” or “off”) |
15 exposure trials, 16 sham trials; exposure duration and interval between trials not indicated; double-blind study |
Verbal report of experiencing any of 4 symptoms during a trial: palpitations, chest pain, vertigo, prickling in the arm | No statistically significant effect of exposure |
Eltiti et al. [21] |
44 IEI-EMF, 114 controls |
GSM 900 MHz, GSM 1800 MHz, UMTS base station signals; combined power flux density of 10 mW/m2 for GSM signal, 10 mW/m2 for UMTS signal |
2 exposure sessions to GSM (combined signal of GSM 900 and GSM 1800 frequencies) or UMTS signal and 1 sham session, each 50 min; sessions were separated by at least 1 week; double-blind study |
Assigned scores on a 100-mm VAS for rating the severity of 6 symptoms (anxiety, tension, arousal, relaxation, discomfort, and fatigue); assigned levels on symptom scales consisting of a list of 57 symptoms extracted from the Electromagnetic Hypersensitivity Questionnaire [6] | For individuals with IEI-EMF: elevated levels of arousal when exposed to a UMTS signal (p < 0.0025), likely due to a non-balanced design (45% of participants had UMTS exposure in the first of the three sessions): no statistically significant effect when conditions were compared for each session separately; no statistically significant effect for the 6 other items of subjective well-being, nor for symptoms |
Furubayashi et al. [36] | 11 IEI-EMF, 43 controls | 2.14 GHz WCDMA base station signal with power density of 0.265 W/m2; EF at the subjects’ head: 10 V/m, calculated brain SAR10g peak: 0.0078 W/kg |
1 session with continuous exposure, 1 session with intermittent exposure with EMF turned “on” and “off” randomly every 5 min (50% of the time "on"), 1 sham session, 1 noise session, each 30 min; two sessions on 1 day; sessions were separated by at least 2 h; double-blind study |
Assigned level of discomfort on a 5-point scale; assigned scores on a 5-point scale in the Profile of Mood States (POMS) questionnaire [71] for rating the severity of 6 states of mood (tension-anxiety, anger-hostility, depression, vigor, fatigue, confusion) | No statistically significant effect of exposure |
Hietanen et al. [57] | 20 IEI-EMF | Analogue 900 MHz NMT phone (output power: 1 W), digital GSM phone 900 MHz (output power: 0.25 W), digital GSM phone 1800 MHz (output power: 0.125 W); power densities: 2–200 W/m2 |
3 exposure sessions to different signals, 1 sham session, each 30 min; sessions were separated by at least 60 min; double-blind study |
Verbal report of any symptoms and sensations experienced during a trial | Higher number of symptoms was reported for the sham condition than for any of the RF exposures. Statistical significance (p < 0.05) of this effect was explicitly specified only for men. |
Hillert et al. [39] | 38 IEI-EMF, 33 controls | 884 MHz GSM mobile phone-like signal, head (calculated): SAR10g averaged peak spatial 1.4 W/kg |
1 exposure session, 1 sham session, each 3 h; sessions were separated by at least 1 week; double-blind study |
Assigned scores on a 7-point Likert scale for rating the severity of 14 symptoms (headache, fatigue, nausea, vertigo, difficulties concentrating, feeling low-spirited, temporary vision problems, 5 questions on dermal complaints, stress, heat or pain from the left ear), 1 additional category for “other” symptoms |
Headache more commonly reported after RF exposure than after sham (p < 0.001) due to a difference between headache reports during RF and sham in the non-symptom group; no statistically significant effect on increase in percentage reporting headache. No effect of exposure for IEI-EMF participants and no statistically significant effect of exposure for other symptoms. |
Kwon et al. [72] | 17 IEI-EMF, 20 controls | 1950 MHz WCDMA mobile phone-like signals (output power: 24 dB), head: SAR1g 1.57 W/kg (measured and calculated) |
1 exposure session, 1 sham session, each 31 min; sessions were separated by at least 1 day; double-blind study |
Assigned scores on a 4-point scale [40] for rating the severity of 8 symptoms (throbbing, itching, warmth, fatigue, headache, dizziness, nausea, palpitation) | No statistically significant effect of exposure |
Nam et al. [73] | 18 IEI-EMF, 19 controls | 835 MHz CDMA mobile phone (transmission power: 300 mW), SAR1g 1.2 W/kg (according to manufacturer’s information) |
1 exposure session, 1 sham session, each 31 min; sessions were separated by at least 1 day; single-blind study |
Assigned scores on a 4-point scale [40] for rating the severity of 9 symptoms (redness, itching, warmth, fatigue, headaches, dizziness, nausea, palpitation, indigestion) | No statistically significant effect of exposure |
Nieto-Hernandez et al. [58] | 60 IEI-EMF, 60 controls | 385.25 MHz continuous wave signal, 385.25 MHz TETRA handset-like signal (pulsing frequency of 16 Hz), output power each 250 mW; close to the antenna SAR10g 1.3 W/kg |
2 exposure sessions to different signals, 1 sham session, each 50 min; sessions were separated by at least 1 day; double-blind study |
Assigned scores in the Positive and Negative Affect Schedule (PANAS) questionnaire [74]; assigned scores on an 11-point numerical scale for rating the severity of 8 symptoms (headache; fatigue; dizziness; nausea; sensations of warmth or burning on skin; skin itching, tingling, stinging or numbness; feeling irritable, anxious or depressed; difficulty concentrating or thinking) |
Before correction for multiple comparisons For TETRA signal: increased difficulty concentrating. For continuous wave signal: increased ratings of headache in all participants (p = 0.004), fatigue showed reduced initial rating (p < 0.0001) and faster increase (p = 0.014) in non-sensitive participants, increased difficulty concentrating (p = 0.037) and reduced sensations of itching in IEI-EMF individuals. After correction for multiple comparisons No statistically significant effect of exposure for TETRA signal. For continuous wave signal: reduced sensations of itching in IEI-EMF individuals (p = 0.03) |
Oftedal et al. [22] | 17 IEI-EMF | 902.4 MHz GSM mobile phone-like signal, maximum output power 23 dBm ( ~̴0.2 W), head SAR10g peak spatial = 0.8 W/kg |
Up to 4 exposure sessions and up to 4 sham sessions, each 30 min, sessions were separated by at least 2 days; double-blind study |
Assigned scores on a 100- mm VAS for rating the severity of pain/discomfort in the head and “other” symptoms | No statistically significant effect of exposure |
Regel et al. [23] | 33 IEI-EMF, 84 controls | 2.140 MHz UMTS base station-like signal, 1 V/m (brain SAR10g peak spatial: 45 μW/kg (calculated)) or 10 V/m (brain SAR10g peak spatial: 4500 W/kg (calculated)) |
2 exposure sessions to different intensities, 1 sham session, each 45 min; sessions were separated by 1 week; double-blind study |
Scores in the questionnaire on the Current Disposition [75]; scores in the modified Quality-of-Life questionnaire [76] (23 items within 5 subscales: anxiety, somatic symptoms, inadequacy, depression, hostility) | No statistically significant effect of exposure |
Rubin et al. [77] |
60 IEI-EMF, 60 controls |
900 MHz GSM mobile phone, continuous wave signal, SAR 1.4 W/kg (near to the antenna) |
2 exposure sessions to different signals, 1 sham session; each 50 min; sessions were separated by at least 1 day; double-blind study |
Assigned scores on a 100-mm VAS for rating the severity of 7 symptoms (headaches; nausea; fatigue; dizziness; skin itching, tingling, or stinging; sensations of warmth or burning on skin; eye pain or dryness) | No statistically significant effect of exposure |
Verrender et al. [78] | 3 IEI-EMF | 902–928 MHz RF signal, average output power: 1 W; power density: 0.3 W/m2 |
6 exposure sessions and 6 sham sessions, each 30 min; separated by at least 1 h; double-blind study |
Assigned scores on a 100-mm VAS for rating the severity of the most immediate symptom triggered during the open provocation | No statistically significant effect of exposure |
Wallace et al. [79] | 48 IEI-EMF, 132 controls | 420 MHz TETRA base station signal, 10 mW/m2, estimated SAR: 271 μW/kg |
1 exposure session, 1 sham session, each 50 min; sessions were separated by at least 1 week; double-blind study |
Assigned scores on a 100- mm VAS for rating the severity of 6 symptoms (anxiety, tension, arousal, relaxation, discomfort, and fatigue); assigned levels on symptom scales consisting of a list of 57 symptoms extracted from the Electromagnetic Hypersensitivity Questionnaire [6] |
No statistically significant effect of exposure |
Wilén et al. [33] | 20 IEI-EMF, 20 controls | 900 MHz GSM mobile phone-like signal, SAR10g: 0.8 W/kg (calculated) |
1 exposure session, 1 sham session, each 30 min; sessions were separated by at least 1 day; single-blind study |
Report of any symptoms experienced during a trial using a follow-up form | No statistically significant effect of exposure |
Various | |||||
Rea et al. [54] |
Experiment 1: 100 IEI-EMF; Experiment 2: 25 IEI-EMF, 25 controls; Experiment 3: 16 IEI-EMF |
MF pulses of various frequencies between 0.1 Hz and 5 MHz, at hand level: 70 nT, at knee level: 350 nT, at floor level: 2900 nT | Experiment 1 and 2: 21 exposure trials at different frequencies, 5 sham trials; experiment 3: 1 exposure trial and 5 sham trials on two separate occasions, each 3 min; interval between trials not reported | Report of any symptoms experienced during a trial | 16 out of 100 participants reported consistent reactions to exposure in all three experiments, but not to sham; no statistical analysis |