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. 2019 Oct 22;39:20. doi: 10.1186/s41232-019-0109-x

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Schematic representation of FGF-FGFR signaling pathways and mechanisms in osteogenesis. The regulation of osteogenesis by FGF and FGFR. FGF/FGFR signaling is an important regulator of osteoblastogenesis, and that control osteoblast replication and differentiation. Activation of FGF and FGFR triggers the activation of ERK1/2 MAPK, PLCγ/PKC, and Akt activity which upregulate osteoblast gene expression and osteogenesis. Abbreviations: FGF, fibroblast growth factor; FGFR, fibroblast growth factor receptors