. 2019 Oct 21;38:421. doi: 10.1186/s13046-019-1430-6

Table 1.

Effect of MCPIP1 on gene expression. Regulation of genes expression and proteins level by MCPIP1 was tested both in cells with ZC3H12A overexpression or silencing. Cited results were obtained from studies using cells cultured in control conditions. We did not include data obtained upon induction of differentiation (i.e. adipogenesis), nor stimulation (i.e. cytokines, LPS)

MCPIP1 OVEREXPRESSION
gene expression	Experimental model	Reference
HIF-1α, VEGF1, cdh12, cdh19, VE-cadherin^a	HUVECs	Niu et al., 2008 [27]
Ephrin-A1, IL-1β, Notch Homolog 4, Ephrin B2, PDGF α, TIMP-2, Ephrin A3, Midkine, Thrombospondin 1, CSF-3^b	HUVECs	Niu et al., 2008 [27]
Flt-1, Flk-1, Tie-2, CD31, Beclin-1^a	bone marrow mononuclear cells	Niu et al., 2013 [28]
VEGF, COX2, SIRT-1^a	HUVECs	Roy et al., 2013 [29]
Fas, Dedd2^a	MDA-MB-231	Lu et al., 2016 [30]
MBLN2, SLC3A2, DFFB, APAF1^a	BE(2)-C human neuroblastoma cell line	Boratyn et al., 2016 [31]
CDKN1A^{a, c}	ccRCC cell line Caki-1	Lichawska-Cieslar et al., 2018 [32]
gene expression	Experimental model	Reference
CD14, CD11b^a	bone marrow mononuclear cells	Niu et al., 2013 [28]
TSP-1 and VEGI, p65	HUVECs	Roy et al., 2013 [29]
Bcl2L1, Bcl2A1, Birc3, RelB, and Bcl3^a	MDA-MB-231	Lu et al., 2016 [30]
CTXN1, CNIH2, MCM10, CD248, RBM12, PAXIP1, SEPT3^a	BE(2)-C human neuroblastoma cell line	Boratyn et al., 2016 [31]
SLC44A1, SLC29A4,	BE(2)-C human neuroblastoma cell line	Boratyn et al., 2016 [31]
IL-6, VEGF, GLUT-1^a	ccRCC cell line Caki-1	Ligeza et al., 2017 [33]
c/EBPβ, SDF-1, Snail, Zeb2^a	ccRCC cell line Caki-1	Marona et al., 2017 [34]
HSPA5, AGR2, PLOD2, MMP2, NDRG1, NDRG2, SPHK1, ENPP2,	ccRCC cell line Caki-1	Lichawska-Cieslar et al., 2018 [32]
NGEF, GPRC5B, TSC22D3, SGK2, FRAT1, RIPK4, DDB1 ^{a, c}	ccRCC cell line Caki-1	Lichawska-Cieslar et al., 2018 [32]
MCPIP1 SILENCING
gene expression	Experimental model	Reference
BCL2L1, BCL3, BIRC3, RELB, AND BCL2A1	MDA-MB-231	Lu et al., 2016 [30]
IL-8, VEGF, IL-6, c/EBPβ, SDF-1, CXCR4, Snail, Zeb2^a	ccRCC cell line Caki-1	Marona et al., 2017 [34]

^aReal-time PCR analysis

^bGene array analysis; expression profile of angiogenesis-related genes in GFP/hMCPIP-over GFP-infected HUVECs with fold induction > 5

^cRNA-Seq analysis