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. 2019 Oct 21;19:271. doi: 10.1186/s12935-019-0977-9

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 10 — The molecular mechanism of miR-129-5p regulation of ZIC2 expression and the Wnt/β-catenin signaling pathway in PCa. In PCa, the expression of miR-129-5p was significantly decreased, while the expression of ZIC2 was significantly increased. miR-129-5p targeted ZIC2 and inhibited the expression of ZIC2. The up-regulated miR-129-5p could suppresses the expression of ZIC2, leading to reduced expression of Wnt, β-catenin, N-cadherin and vimentin with increase in E-cadherin expression. Eventually, up-regulated miR-129-5p significantly inhibited cell proliferation, migration, invasion and EMT while promoting PCa cell apoptosis