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. 2019 Oct 21;19:270. doi: 10.1186/s12935-019-0992-x

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Regulatory effects of HOTAIR on cell migration and progression of CSCC cells. a, b Transwell assay shows the migration of A431 transfected with HOTAIR siRNAs and SCL-1 transfected with HOTAIR OE plasmids. Images are harvested under a light microscope (×200). c, d Wound healing assay shows the migration of A431 transfected with HOTAIR siRNAs and SCL-1 transfected with HOTAIR OE plasmids. e Transfection with HOTAIR siRNAs in A431 promotes the expression of E-cadherin and inhibited the expressions of N-cadherin, Twist, Snail1 and ZEB1. Transfection with HOTAIR OE plasmids in SCL-1 represses the expression of E-cadherin and promotes N-cadherin and Twist expressions. Data are presented as mean ± SD. *P < 0.05; siRNA NC, siRNA negative control group; vector, overexpression plasmid vector negative control group