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. 2019 Oct 22;17:133. doi: 10.1186/s12964-019-0453-0

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Notch pathway amplifies intrinsic noise by interactions that improve the efficiency of global protein synthesis. Schematic image shows interaction of a sender (Jag⁺) and a receiver (Notch⁺) and downstream molecular events instructed by these interactions. System-level interactions of Notch pathway lead to enhanced availability of Myc. Global amplification of protein synthesis following upregulated activity of Myc amplifies noise by distorting the stoichiometric relationship between transcripts and associated proteins