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. 2019 Oct 22;17:133. doi: 10.1186/s12964-019-0453-0

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Altered topology of the Wnt/β-catenin pathway in Notch^on cells. a Left panels show network topology of simple feedback loops that regulate signalling output of the Wnt/β-catenin pathway in the Notch^off and the Notch^on states. Line diagrams (right) show predicted impact of altered network topology the Notch^on state on cytoplasmic availability of β-catenin, p53, and Myc. b Modeling demonstrates time course of equilibration of Myc and β-catenin subsequent to activation in the Notch^off and the Notch^on states. Kinetic biochemical modeling was accomplished using VCell software