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. 2019 Oct 22;17:133. doi: 10.1186/s12964-019-0453-0

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Noise-induced bistability and resolution of fate dichotomies. a Integrated view of global network topology of Wnt/PI3K/Myc axis following integration of the Notch signaling pathway. b It is proposed that Notch signaling input combines enhanced autophagic flux with amplifications of translational noise in order to destabilize the existing cellular memory (i.e. destabilize thermodynamic stability) and to invoke bistability prior to biological decision-making. Resolution of such bistability requires integration of exogenous cues that amplify or terminate the Notch signalling pathway