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The autoimmune disease in R2−/− mice is dependent on MAVS but independent of type I IFNs and STING. (A–C) Serum ANA levels of the indicated mice (5-month old) were measured by the Hep2 system. (D,E) Spleen weights were measured in 5-month old mice indicated. Each symbol represents a mouse. ***p < 0.001 (One-way ANOVA test); ns, not significant.
