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. 2019 Oct 16;10:2452. doi: 10.3389/fimmu.2019.02452

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Copyright © 2019 Sun, Wang, Qi, Wu, Scott and Bolland.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MAVS deficiency prevents spontaneous GCs in R2^−/− mice. Splenocytes from the indicated mice were stained with antibodies and analyzed by flow cytometry. (A) GC B cells (FAS⁺GL-7⁺) were gated on B220⁺ lymphocytes. (B) Plasma cells/plasmablasts (PCs/PBs, CD138⁺B220^lo) were gated on lymphocytes. (C) Tfh cells (PD-1⁺CXCR5⁺) were gated on CD4⁺CD62L⁻CD44⁺ cells. The numbers are percentages of cells falling in each gate. (D) A summary of multiple mice analyzed as in A–C. Each symbol represents a mouse. ^*p < 0.05; ^**p < 0.01 (One-way ANOVA). ns, not significant. (E) Histological analysis of spleen sections for GCs (stained with PNA, dark brown).