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. 2019 Oct 16;10:2452. doi: 10.3389/fimmu.2019.02452

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Copyright © 2019 Sun, Wang, Qi, Wu, Scott and Bolland.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The autoimmune modulatory effect of MAVS in R2^−/− mice is independent on the TLR7 signaling. (A) The expression levels of Tlr7 mRNA in purified B cells from the indicated mice were determined by qPCR. (B) Serum levels of IL-6 and TNF-α detected 6 h after a single injection with imiquimod (50 μg per mouse i.v.). The data are means ± SEM of 3 mice. (C) Proliferative response of B cells to imiquimod in vitro. Purified B cells (over 97% purity) were labeled with CFSE and cultured with 2 μg/ml of imiquimod for 3 days. Cells were then analyzed by flow cytometry. Data are representative of at least three independent experiments. ns, not significant.