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. 2019 Oct 16;10:2452. doi: 10.3389/fimmu.2019.02452

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Copyright © 2019 Sun, Wang, Qi, Wu, Scott and Bolland.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The regulatory effect of MAVS on autoimmunity is bone marrow dependent. (A–E) BM chimera mice were generated using donors of Mavs^+/+R2^−/− or Mavs^−/−R2^−/− mice and recipients of B6 or Mavs^−/−. Two months after reconstitution, spleen weights (A) and serum ANA levels (B) of recipients were measured. (C,D) Splenic GCs, plasma cells/plasmablasts (PCs/PBs), CD69⁺ B cells, and CD45RB⁻ CD4 T cells were analyzed by flow cytometry. Each symbol represents a mouse. (E) Histological analysis of spleen and kidney sections for GCs (top panel, stained with PNA, dark brown) and glomeruli (bottom panel, stained with H&E). The kidney pathology scores of multiple mice are shown in right panel. Each symbol represents a mouse. ^*p < 0.05; ^**p < 0.01 (One-way ANOVA test).