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. 2019 Oct 16;10:2452. doi: 10.3389/fimmu.2019.02452

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Copyright © 2019 Sun, Wang, Qi, Wu, Scott and Bolland.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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BM chimera mice confirm the B cell intrinsic effect of MAVS on activation and antibody secretion. (A–D) Mixed BM chimera mice were generated with donor BM at a 1:1 ratio. (B) Two months following reconstitution, the numbers of total B (left panel) and GC B cells (right panel) in recipients were analyzed by flow cytometry. (C) The ANA reactivity with an origin of either IgG2a/c [Igh^b] (top panel) or IgG2a/c[Igh^a] (bottom panel) was determined by using the Hep2 system. (D) A summary of ANA scores of multiple mice. (E,F) Donor BM was mixed at the indicated ratio and transferred into recipient mice. The total B cells (E) and GC B cells (F)of the donor origins were analyzed by flow cytometry and enumerated. Data are means ± SEM of 5–8 mice per group (A–F). ^*p < 0.05; ^**p < 0.01; ^***p < 0.001 (One-way ANOVA test).