Table 4.

Classification results for AD vs. HC, MCIs vs. MCIc, AD vs. MCIs, AD vs. MCIc, HC vs. MCIc, and HC vs. MCIs groups.

Groups	Features	Classifier	Performance measure
			AUC	ACC	SEN	SPEC	PRE	F1-score	Cohen's kappa
AD vs. HC	APOE genotype	SVM	90.83	88.96	90.91	89.46	86.92	87.33	0.79
	CSF		91.54	91.3	88.48	91.67	90.91	93.15	0.82
	sMRI		93.33	92.5	100	89.74	88.47	92.86	0.85
	FDG-PET		92.5	92.56	89.74	90	93.62	91.63	0.84
	Combined		98.33	98.42	100	96.47	97.89	98.42	0.93
MCIs vs. MCIc	APOE genotype	SVM	91.21	92	86.67	100	100	92.86	0.83
	CSF		87.73	88	85.71	90.91	92.31	88.89	0.75
	sMRI		86.54	85.43	84.55	83.92	86.96	81.82	0.69
	FDG-PET		90.38	89	100	85	76.92	86.96	0.76
	Combined		93.59	94.86	100	88.71	89.62	91.67	0.86
AD vs. MCIs	APOE genotype	SVM	90	89.96	100	82.73	84	88.89	0.75
	CSF		94.17	93.33	91.3	100	86.67	92.86	0.86
	sMRI		88.33	87.67	82.61	86.49	73.33	84.62	0.73
	FDG-PET		89.17	90	89.96	91.73	89.96	88.89	0.75
	Combined		96.83	96.65	100	91.67	93.33	96.55	0.91
AD vs. MCIc	APOE genotype	SVM	88.89	88.46	77.78	94.12	87.2	82.35	0.71
	CSF		89.58	86.39	86.92	90	87.5	88.67	0.73
	sMRI		84.52	80.36	80.77	81.82	80	78.26	0.69
	FDG-PET		84.03	80.77	66.67	88.24	75	70.59	0.65
	Combined		94.64	92.26	91.67	92.86	91.67	91.67	0.84
HC vs. MCIc	APOE genotype	SVM	87.5	87.12	82.64	87.5	86.67	92.33	0.73
	CSF		94.05	92.31	91.67	90.44	92.26	95.22	0.83
	sMRI		89.58	88.46	90.91	86.67	83.33	86.96	0.76
	FDG-PET		91.07	87.5	88.46	100	82.35	85.71	0.76
	Combined		96.43	94.13	94.75	100	100	96.72	0.88
HC vs. MCIs	APOE genotype	SVM	90.83	87.08	86.96	92.86	86.67	89.66	0.72
	CSF		92.5	90.47	100	72.73	80	88.89	0.73
	sMRI		91.27	90.16	98.26	86.67	90.91	92	0.71
	FDG-PET		89.68	87.3	92.31	80	85.71	88.89	0.73
	Combined		95.24	95.65	100	88.89	93.33	96.55	0.90