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. 2019 Oct 16;9:1014. doi: 10.3389/fonc.2019.01014

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Copyright © 2019 Soleyman-Jahi, Sadeghi, Pastaki Khoshbin, Khani, Roosta and Zendehdel.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Overview of biological functions of ghrelin in body. Ghrelin is mainly produced in des-acylated form by gastric oxyntic gland and is acylated to active ghrelin by GOAT enzyme. Ghrelin exerts its biological effects through binding to GHR-1, which is expressed predominantly on hypothalamus and less on other organs. In contrast, des-acylated ghrelin functions as ghrelin antagonist and inhibits the function of ghrelin.