Figure 3.

Pathways and molecules inhibited by sorafenib, regorafenib, cabozantinib, ramucirumab and lenvatinib. Red Xs indicate inhibition by sorafenib, blue Xs indicate inhibition by regorafenib, yellow Xs indicate inhibition by cabozantinib, green Xs indicate inhibition by lenvatinib, and purple Xs indicate inhibition by ramucirumab.

Abbreviations: ERK, extracellular signal-regulated kinase; MEK, mitogen-activated protein kinase kinase; Raf, RAF proto-oncogene serine/threonine-protein kinase; Ras, Ras GTPases; FGFR, fibroblast growth factor receptor; VEGFR, vascular endothelial growth factor receptor; PDGFR, platelet-derived growth factor receptor; RTKs, receptor tyrosine kinase; PDGFRA, platelet-derived growth factor receptor A; EGFR, epidermal growth factor receptor; PI3K, phosphoinositide 3-kinase; Mcl-1, induced myeloid leukemia cell differentiation protein; eIF4E, eukaryotic translation initiation factor 4E.